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?:abstract
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OBJECTIVE: To investigate pregnancy outcomes and compare the clinical characteristics of coronavirus 2019 (COVID-19) disease in pregnant and agematched non-pregnant women MATERIALS AND METHODS: Hospital records of four tertiary care centers were reviewed retrospectively The subjects comprised 188 pregnant patients and 799 non-pregnant women who were admitted to these hospitals RESULTS: Pregnancy significantly affected the clinical severity of COVID-19 and this effect was more prominent in pregnant women at >20 weeks gestation (p<0 001) Rates of oxygen support (10 1% vs 4 8%;p≤0 001), intensive care unit admission (3 2% vs 0 6%;p=0 009), presence of fever (12 8% vs 4 4%;p<0 001), tachypnea (7 0% vs 2 4%;p=0 003) and tachycardia (16 0% vs 1 9%;p<0 001) were significantly more frequent in pregnant women compared with non-pregnant women Pregnancy was strongly associated with the need for oxygen support [relative risk (RR), 2 125;95% confidence interval (CI): 1 25-3 60] and admission to the intensive care unit (RR, 5 1;95% CI: 1 57-16 53) compared with non-pregnant women Some 14 4% of the pregnant women had co-morbidities Sixty of the 188 pregnant women (31 9%) delivered during the Severe Acute Respiratory syndrome coronavirus-2 infection, 11 (18 3%) had vaginal deliveries and 49 (81 7%) were by cesarean section Of these 60 deliveries, 40 (66 7%) were <37 weeks gestation CONCLUSION: Pregnancy worsens the morbidity of COVID-19 and this effect seems to increase as the pregnancy advances, but not the mortality rate
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