PropertyValue
?:abstract
  • In this study, anti‐SARS‐CoV‐2 activity of mycophenolic acid (MPA) and IMD‐0354 was analyzed, these compounds were chosen based on their antiviral activities against other coronaviruses. Since they also inhibit Dengue virus (DENV) infection, other anti‐DENV compounds/drugs were also assessed. Using SARS‐CoV‐2‐infected VeroE6/TMPRSS2 cells, MPA and IMD‐0354, but not other anti‐DENV compounds/drugs, showed significant anti‐SARS‐CoV‐2 activity. Although MPA reduced the viral RNA level by only ~100‐fold, its EC(50) was as low as 0.87µM, which is easily achievable at therapeutic doses of mycophenolate mofetil. MPA targets coronaviral papain‐like protease and its study would be useful in the development of novel anti‐SARS‐CoV‐2 drugs. This article is protected by copyright. All rights reserved.
?:creator
?:doi
?:doi
  • 10.1111/1348-0421.12828
?:journal
  • Microbiol_Immunol
?:license
  • no-cc
?:pmcid
?:pmid
?:pmid
  • 32579258.0
?:publication_isRelatedTo_Disease
?:source
  • Medline; PMC
?:title
  • Antiviral activities of mycophenolic acid and IMD‐0354 against SARS‐CoV‐2
?:type
?:year
  • 2020-06-24

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