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?:abstract
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This review focuses an alternative strategy utilizing small molecules to inhibit a key signal-transduction pathway, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The JAK-STAT pathway mediates biologic activity for a large number of inflammatory cytokines and mediators.
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?:doi
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?:doi
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?:journal
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Cleveland_Clinic_journal_of_medicine
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?:pmid
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?:source
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?:title
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Cytokine storm release syndrome and the prospects for immunotherapy with COVID-19, part 4: The role of JAK inhibition.
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