dphf4et

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?:abstract	Study Objectives: As the upcoming influenza season aligns with a forecasted second wave of COVID-19, diagnostics are needed to effectively and efficiently differentiate between the two Point-of-care ultrasound (POCUS) is already widely used in the evaluation of cardiopulmonary dysfunction in the emergency setting, but scant research has been performed into the diagnostic implications of POCUS in patients with suspected influenza This study investigated the utility of cardiopulmonary ultrasound as a novel diagnostic tool for patients with influenza Methods: A convenience sample of patients presenting to an urban academic ED with influenza-like symptoms who received polymerase chain reaction (PCR) influenza testing were enrolled An ultrasonographer blinded to influenza results performed a POCUS using the CLIFF (Cardiac, Lungs, IVC, and Free fluid-t) protocol POCUS scans were performed by emergency medicine attendings, ultrasound fellows, or advanced practice providers who received 1-hour training in the CLIFF protocol Clinical data including demographics, relevant comorbidities, and influenza vaccine status as well as laboratory values, interventions, and disposition were retrospectively collected POCUS findings of PCR positive flu cases were then compared to PCR flu negative cases Descriptive analysis using Fisher’s exact test was used to compare the two groups’ findings A subgroup analysis adjusting for heart failure was then performed Results: A total of 117 patients were enrolled, of which 41 9% (49/117) tested positive for the flu Patients with flu negative had a higher rate of hospitalization (75 0%, 51/68;36 8% 25/117) and found to have more comorbidities including congestive heart failure (57 1%, 28/49;8 2% 4/49) (P=0 046;p=0 001) A subgroup analysis adjusted for CHF showed no statistical difference in POCUS findings of pulmonary b-lines (65 7%, 23/35;42 5%, 17/40;p=0 075), a-lines (85 7%, 30/35;82 5%, 33/40;p=0 95), consolidations (28 6%, 10/35;15%, 6/40;p=0 251) in cases with flu positive and negative Non-flu patients also showed significantly depressed EF as compared to flu-positive patients (25/68, 36 8%;4/38, 8 33%;p= 001), as well as significantly higher levels of RV dysfunction (8/68, 14%;1/48, 2 17%) and IVC dilation (15/68, 23 1%;2/48, 4 44%;p= 027) The proportion of patients with normal EF was higher in patients with flu compared to patients without flu (85 0% vs 65 7%, P = 0 042) Mild RV dilation was more prevalent in flu-negative patients Conclusion: In ED patients with suspected influenza, a POCUS CLIFF protocol showed no difference in cardiopulmonary findings in patients with confirmed influenza as compared to those who tested negative Further studies comparing POCUS cardiopulmonary findings of influenza compared to COVID-19 are needed [Formula presented]
is ?:annotates of	<https://research.tib.eu/covid-19/entity/7dphf4et_hasAnnotation_C0012359> <https://research.tib.eu/covid-19/entity/7dphf4et_hasAnnotation_C0013227> <https://research.tib.eu/covid-19/entity/7dphf4et_hasAnnotation_C0013687> <https://research.tib.eu/covid-19/entity/7dphf4et_hasAnnotation_C0392171> <https://research.tib.eu/covid-19/entity/7dphf4et_hasAnnotation_C1421479>
?:creator	<https://research.tib.eu/covid-19/entity/Shokoohi%2C_H.%3B_Al_Saud%2C_A.%3B_Goldsmith%2C_A.%3B_Schulwolf%2C_S.%3B_Eke%2C_O.%3B_Al_Mulhim%2C_A.%3B_Huang%2C_C.%3B_Kharasch%2C_S.%3B_Liteplo%2C_A.>
?:journal	Annals_of_Emergency_Medicine
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/7dphf4et_HAS_C0021400_CAUSES_C0392171>
?:source	WHO
?:title	161 Cardiopulmonary Ultrasound in Risk Stratification of Patients With Influenza
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#898405
?:year	2020

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?:abstract

Study Objectives: As the upcoming influenza season aligns with a forecasted second wave of COVID-19, diagnostics are needed to effectively and efficiently differentiate between the two Point-of-care ultrasound (POCUS) is already widely used in the evaluation of cardiopulmonary dysfunction in the emergency setting, but scant research has been performed into the diagnostic implications of POCUS in patients with suspected influenza This study investigated the utility of cardiopulmonary ultrasound as a novel diagnostic tool for patients with influenza Methods: A convenience sample of patients presenting to an urban academic ED with influenza-like symptoms who received polymerase chain reaction (PCR) influenza testing were enrolled An ultrasonographer blinded to influenza results performed a POCUS using the CLIFF (Cardiac, Lungs, IVC, and Free fluid-t) protocol POCUS scans were performed by emergency medicine attendings, ultrasound fellows, or advanced practice providers who received 1-hour training in the CLIFF protocol Clinical data including demographics, relevant comorbidities, and influenza vaccine status as well as laboratory values, interventions, and disposition were retrospectively collected POCUS findings of PCR positive flu cases were then compared to PCR flu negative cases Descriptive analysis using Fisher’s exact test was used to compare the two groups’ findings A subgroup analysis adjusting for heart failure was then performed Results: A total of 117 patients were enrolled, of which 41 9% (49/117) tested positive for the flu Patients with flu negative had a higher rate of hospitalization (75 0%, 51/68;36 8% 25/117) and found to have more comorbidities including congestive heart failure (57 1%, 28/49;8 2% 4/49) (P=0 046;p=0 001) A subgroup analysis adjusted for CHF showed no statistical difference in POCUS findings of pulmonary b-lines (65 7%, 23/35;42 5%, 17/40;p=0 075), a-lines (85 7%, 30/35;82 5%, 33/40;p=0 95), consolidations (28 6%, 10/35;15%, 6/40;p=0 251) in cases with flu positive and negative Non-flu patients also showed significantly depressed EF as compared to flu-positive patients (25/68, 36 8%;4/38, 8 33%;p= 001), as well as significantly higher levels of RV dysfunction (8/68, 14%;1/48, 2 17%) and IVC dilation (15/68, 23 1%;2/48, 4 44%;p= 027) The proportion of patients with normal EF was higher in patients with flu compared to patients without flu (85 0% vs 65 7%, P = 0 042) Mild RV dilation was more prevalent in flu-negative patients Conclusion: In ED patients with suspected influenza, a POCUS CLIFF protocol showed no difference in cardiopulmonary findings in patients with confirmed influenza as compared to those who tested negative Further studies comparing POCUS cardiopulmonary findings of influenza compared to COVID-19 are needed [Formula presented]

is ?:annotates of