PropertyValue
?:abstract
  • COVID-19, an infectious contagious viral (SARS-CoV-2) disease, associated with morbidity and mortality from respiratory pandemic worldwide Currently, COVID-19 has no targeted treatment strategies and has been declared by WHO as a global health emergency SARS-CoV-2, an enveloped, positive-sense, betacoronavirus (βCoV) spreading rapidly due to its potential pre-and asymptomatic transmission (silent transmission) The viral replicase single-stranded genome encodes for two open reading frame genes (orf1a and orf1b), that are translated into two polyproteins, pp1a and pp1b Viral proteases including papain-like protease (PL-PRO) and chymotrypsin-like protease (3CL-PRO) pre-processes and fragments the polyproteins into 16 non-structural proteins (Nsps) that are assembled into replicase-transcriptase complex and exhibit multiple enzymatic activity To rationalize their evolutionary success and develop improved control strategies, understanding the main functions and interactions of non-structural proteins of SARS-CoV-2 will be essential Based on the existing published literature, this review summarizes the knowledge on multiple pathologic functions of Nsps in COVID-19 This review is hoped to help the researchers to understand the significant role of non-structural proteins in COVID-19 and provide a reference for future studies
is ?:annotates of
?:creator
?:journal
  • Indian_Journal_of_Pharmaceutical_Education_and_Research
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Sars-cov-2: The prominent role of non-structural proteins (nsps) in COVID-19
?:type
?:who_covidence_id
  • #922925
?:year
  • 2020

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