PropertyValue
?:abstract
  • A recent genetic association study (Ellinghaus et al. 2020) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure in SARS-CoV-2. Recent data comprising 3,199 hospitalized COVID-19 patients and controls reproduce this and find that it is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neandertals and occurs at a frequency of ~30% in south Asia and ~8% in Europe.
?:creator
?:doi
  • 10.1101/2020.07.03.186296
?:doi
?:externalLink
?:journal
  • bioRxiv
?:license
  • biorxiv
?:pdf_json_files
  • document_parses/pdf_json/9578520100307e264cb64642a343d4d37fb3bc39.json
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • BioRxiv
?:title
  • The major genetic risk factor for severe COVID-19 is inherited from Neandertals
?:type
?:year
  • 2020-07-03

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