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?:abstract
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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an enveloped, single-stranded RNA virus Humans infected with SARS-CoV-2 develop a disease known as coronavirus disease 2019 (COVID-19) with symptoms and consequences including acute respiratory distress syndrome (ARDS), cardiovascular disorders, and death SARS-CoV-2 appears to infect cells by first binding viral spike proteins with host protein angiotensin-converting enzyme 2 (ACE2) receptors;the virus is endocytosed following priming by transmembrane protease serine 2 (TMPRSS2) The process of virus entry into endosomes and its release from endolysosomes are key features of enveloped viruses Thus, it is important to focus attention on the role of endolysosomes in SARS-CoV-2 infection Indeed, coronaviruses are now known to hijack endocytic machinery to enter cells such that they can deliver their genome at replication sites without initiating host detection and immunological responses Hence, endolysosomes might be good targets for developing therapeutic strategies against coronaviruses Here, we focus attention on the involvement of endolysosomes in SARS-CoV-2 infection and COVID-19 pathogenesis Further, we explore endolysosome-based therapeutic strategies to restrict SARS-CoV-2 infection and COVID-19 pathogenesis © Copyright © 2020 Khan, Chen and Geiger
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