vcksn5f

Property	Value
?:abstract	BACKGROUND AND AIMS: Given the limited information describing the connection between metabolic syndrome (MetS) and Coronavirus Disease 2019 (COVID-19), we aimed to assess the impact of MetS on morbidity and mortality among COVID-19 patients. METHODS: This retrospective cohort study was performed from 1st April to May 3, 2020 on 157 ICU-admitted COVID-19 patients in Shahid Modarres Hospital in Tehran, Iran. Patients’ clinical, laboratory and radiological findings, and subsequent complications, were collected and compared between MetS and non-MetS groups. RESULTS: 74 of all cases had MetS. Among the MetS components, waist circumference (p-value = 0.006 for men; p-value<0.0001 for women), Triglycerides (p-value = 0.002), and Fasting Blood Sugar (p-value = 0.007) were significantly higher in MetS group; with no statistical difference found in HDL levels (p-value = 0.21 for men; p-value = 0.13 for women), systolic blood pressure(p-value = 0.07), and diastolic blood pressure (p-value = 0.18) between two groups. Length of ICU admission (p-value = 0.009), the need for invasive mechanical ventilation (p-value = 0.0001), respiratory failure (p-value = 0.0008), and pressure ulcers (p-value = 0.02) were observed significantly more in MetS group. The Odds Ratio (OR) of mortality with 0(OR = 0.3660), 1(OR = 0.5155), 2(OR = 0.5397), 3(OR = 1.9511), 4(OR = 5.7018), and 5(OR = 8.3740) MetS components showed an increased mortality risk as the components’ count increased. The patient with BMI>40 (OR = 6.9368) had more odds of fatality comparing to those with BMI>35 (OR = 4.0690) and BMI>30 (OR = 2.5287). Furthermore, the waist circumference (OR = 8.31; p-value<0.0001) and fasting blood sugar (OR = 2.4588; p-value = 0.0245) were obtained by multivariate logistic regression as independent prognostic factors for mortality. CONCLUSION: The findings suggest a strong relationship between having MetS and increased risk of severe complications and mortality among COVID-19 ICU-admitted patients.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/8vcksn5f_hasAnnotation_C0005802> <https://research.tib.eu/covid-19/entity/8vcksn5f_hasAnnotation_C0009566> <https://research.tib.eu/covid-19/entity/8vcksn5f_hasAnnotation_C1415068> <https://research.tib.eu/covid-19/entity/8vcksn5f_hasAnnotation_C1825598> <https://research.tib.eu/covid-19/entity/8vcksn5f_hasAnnotation_C3715113>
?:creator	<https://research.tib.eu/covid-19/entity/Alamdari%2C_Nasser_Malekpour%3B_Rahimi%2C_Fateme_Sadat%3B_Afaghi%2C_Siamak%3B_Zarghi%2C_Afshin%3B_Qaderi%2C_Shohra%3B_Tarki%2C_Farzad_Esmaeili%3B_Ghafouri%2C_Seyed_Reshad%3B_Besharat%2C_Sara>
?:doi	10.1016/j.dsx.2020.10.012
?:doi	<https://research.tib.eu/covid-19/entity/10.1016/j.dsx.2020.10.012>
?:journal	Diabetes_Metab_Syndr
?:license	no-cc
?:pdf_json_files	document_parses/pdf_json/e59b06bad36ad6e0a32b0104f3010c447efaed42.json; document_parses/pdf_json/fe916aeab8065ce447dc0008163a7ab1e0004671.json
?:pmc_json_files	document_parses/pmc_json/PMC7550894.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7550894>
?:pmid	<https://research.tib.eu/covid-19/entity/33080538.0>
?:pmid	33080538.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/e59b06bad36ad6e0a32b0104f3010c447efaed42%3B%20fe916aeab8065ce447dc0008163a7ab1e0004671>
?:source	Elsevier; Medline; PMC
?:title	The impact of metabolic syndrome on morbidity and mortality among intensive care unit admitted COVID-19 patients
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-10-13

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Value

?:abstract

BACKGROUND AND AIMS: Given the limited information describing the connection between metabolic syndrome (MetS) and Coronavirus Disease 2019 (COVID-19), we aimed to assess the impact of MetS on morbidity and mortality among COVID-19 patients. METHODS: This retrospective cohort study was performed from 1st April to May 3, 2020 on 157 ICU-admitted COVID-19 patients in Shahid Modarres Hospital in Tehran, Iran. Patients’ clinical, laboratory and radiological findings, and subsequent complications, were collected and compared between MetS and non-MetS groups. RESULTS: 74 of all cases had MetS. Among the MetS components, waist circumference (p-value = 0.006 for men; p-value<0.0001 for women), Triglycerides (p-value = 0.002), and Fasting Blood Sugar (p-value = 0.007) were significantly higher in MetS group; with no statistical difference found in HDL levels (p-value = 0.21 for men; p-value = 0.13 for women), systolic blood pressure(p-value = 0.07), and diastolic blood pressure (p-value = 0.18) between two groups. Length of ICU admission (p-value = 0.009), the need for invasive mechanical ventilation (p-value = 0.0001), respiratory failure (p-value = 0.0008), and pressure ulcers (p-value = 0.02) were observed significantly more in MetS group. The Odds Ratio (OR) of mortality with 0(OR = 0.3660), 1(OR = 0.5155), 2(OR = 0.5397), 3(OR = 1.9511), 4(OR = 5.7018), and 5(OR = 8.3740) MetS components showed an increased mortality risk as the components’ count increased. The patient with BMI>40 (OR = 6.9368) had more odds of fatality comparing to those with BMI>35 (OR = 4.0690) and BMI>30 (OR = 2.5287). Furthermore, the waist circumference (OR = 8.31; p-value<0.0001) and fasting blood sugar (OR = 2.4588; p-value = 0.0245) were obtained by multivariate logistic regression as independent prognostic factors for mortality. CONCLUSION: The findings suggest a strong relationship between having MetS and increased risk of severe complications and mortality among COVID-19 ICU-admitted patients.

is ?:annotates of