PropertyValue
?:abstract
  • Contemporarily to the new SARS-CoV-2 mediated COVID-19 pandemic, a rise in patients with acral chilblain lesions has been described. They manifest late after mild disease or asymptomatic exposure to SARS-CoV-2. Their pathogenic evolution is currently unknown. In biopsies from three patients with acral partially ulcerating chilblain lesions that occurred associated to the COVID-19 pandemic, we analysed the expression of type I interferon induced proteins and signal transduction kinases. Histology demonstrated perivascular and periadnexal lymphohistiocytic infiltrates and endothelial dominated MxA-staining, as well as pJAK1 activation. Our findings demonstrate induction of the type I IFN pathway in lesional sections of COVID-19-associated chilblain-like lesions. This may indicate a local antiviral immune activation status associated with preceding exposure to SARS-CoV-2.
is ?:annotates of
?:creator
?:doi
  • 10.3390/dermatopathology7030010
?:doi
?:journal
  • Dermatopathology_(Basel)
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/26f381cacdbb94f38764d8a6ffe7603afcf8a9d7.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7768511.xml.json
?:pmcid
?:pmid
?:pmid
  • 33291622.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic
?:type
?:year
  • 2020-12-04

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