PropertyValue
?:abstract
  • Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications usually involve the generation of continuous and steady fluid flow over cell monolayers for extended durations, usually a few days. Another technique is to generate a fast high-stress wave over the cells to see the immediate effect of flow-induced stresses. This can be achieved by propagating an air/liquid interface, in other words, a bubble, over cell monolayers. The approach is relevant to the reopening event of fluid-filled lung bronchioles and alveoli during mechanical ventilation therapy of Acute Respiratory Distress Syndrome. This article explains how we generate a stress wave using a parallel plate flow chamber and presents representative results of this wave on cultured lung epithelial cells.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.3390/mps3040065
?:journal
  • Methods_Protoc
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/065121a0402f7953aa9ee393b20c83a1dd337776.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7712398.xml.json
?:pmcid
?:pmid
?:pmid
  • 32987681.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Application of a Flow-Induced Stress Wave and Investigation of Associated Injuries on Cell Monolayers Using a Parallel Plate Flow Chamber
?:type
?:year
  • 2020-09-24

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