lpw4k

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?:abstract	OBJECTIVE: To characterize the demographic and clinical features of pediatric SARS-CoV-2 syndromes and identify admission variables predictive of disease severity. STUDY DESIGN: We conducted a multicenter, retrospective and prospective study of pediatric patients hospitalized with acute SARS-CoV-2 infections and multisystem inflammatory syndrome in children (MIS-C) at eight sites in New York, New Jersey, and Connecticut. RESULTS: We identified 281 hospitalized patients with SARS-CoV-2 infections and divided them into three groups based on clinical features. Overall, 143 (51%) had respiratory disease, 69 (25%) had MIS-C, and 69 (25%) had other manifestations including gastrointestinal illness or fever. Patients with MIS-C were more likely to identify as non-Hispanic black compared with patients with respiratory disease (35% versus 18%, P=.02). Seven patients (2%) died and 114 (41%) were admitted to the ICU. In multivariable analyses, obesity (OR=3.39, 95% CI:1.26-9.10, P=.02) and hypoxia on admission (OR=4.01; 95% CI:1.14-14.15; P=.03) were predictive of severe respiratory disease. Lower absolute lymphocyte count (OR=8.33 per unit decrease in 10(9) cells/L, 95% CI:2.32-33.33, P=.001) and higher C-reactive protein (OR=1.06 per unit increase in mg/dL, 95% CI:1.01-1.12, P=.017) were predictive of severe MIS-C. Race/ethnicity or socioeconomic status were not predictive of disease severity. CONCLUSIONS: We identified variables at the time of hospitalization that may help predict the development of severe SARS-CoV-2 disease manifestations in children and youth. These variables may have implications for future prognostic tools that inform hospital admission and clinical management.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/997lpw4k_hasAnnotation_C0015967> <https://research.tib.eu/covid-19/entity/997lpw4k_hasAnnotation_C0242184> <https://research.tib.eu/covid-19/entity/997lpw4k_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Fernandes%2C_Danielle_M.%3B_Oliveira%2C_Carlos_R.%3B_Guerguis%2C_Sandra%3B_Eisenberg%2C_Ruth%3B_Choi%2C_Jaeun%3B_Kim%2C_Mimi%3B_Abdelhemid%2C_Ashraf%3B_Agha%2C_Rabia%3B_Agarwal%2C_Saranga%3B_Aschner%2C_Judy_L.%3B_Avner%2C_Jeffrey_R.%3B_Ballance%2C_Cathleen%3B_Bock%2C_Joshua%3B_Bhavsar%2C_Sejal_M.%3B_Campbell%2C_Melissa%3B_Clouser%2C_Katharine_N.%3B_Gesner%2C_Matthew%3B_Goldman%2C_David_L.%3B_Hammerschlag%2C_Margaret_R.%3B_Hymes%2C_Saul%3B_Howard%2C_Ashley%3B_Jung%2C_Hee-jin%3B_Kohlhoff%2C_Stephan%3B_Kojaoghlanian%2C_Tsoline%3B_Lewis%2C_Rachel%3B_Nachman%2C_Sharon%3B_Naganathan%2C_Srividya%3B_Paintsil%2C_Elijah%3B_Pall%2C_Harpreet%3B_Sy%2C_Sharlene%3B_Wadowski%2C_Stephen%3B_Zirinsky%2C_Elissa%3B_Cabana%2C_Michael_D.%3B_Herold%2C_Betsy_C.>
?:doi	<https://research.tib.eu/covid-19/entity/10.1016/j.jpeds.2020.11.016>
?:doi	10.1016/j.jpeds.2020.11.016
?:journal	J_Pediatr
?:license	no-cc
?:pdf_json_files	document_parses/pdf_json/2c9a8aa1e65213b4dcdda4657d143b62cdcbbdd6.json
?:pmc_json_files	document_parses/pmc_json/PMC7666535.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7666535>
?:pmid	<https://research.tib.eu/covid-19/entity/33197493.0>
?:pmid	33197493.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/997lpw4k_HAS_C0006560_PREDISPOSES_C5389369>
?:sha_id	<https://research.tib.eu/covid-19/entity/2c9a8aa1e65213b4dcdda4657d143b62cdcbbdd6>
?:source	Elsevier; Medline; PMC
?:title	SARS-CoV-2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-11-14

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Value

?:abstract

OBJECTIVE: To characterize the demographic and clinical features of pediatric SARS-CoV-2 syndromes and identify admission variables predictive of disease severity. STUDY DESIGN: We conducted a multicenter, retrospective and prospective study of pediatric patients hospitalized with acute SARS-CoV-2 infections and multisystem inflammatory syndrome in children (MIS-C) at eight sites in New York, New Jersey, and Connecticut. RESULTS: We identified 281 hospitalized patients with SARS-CoV-2 infections and divided them into three groups based on clinical features. Overall, 143 (51%) had respiratory disease, 69 (25%) had MIS-C, and 69 (25%) had other manifestations including gastrointestinal illness or fever. Patients with MIS-C were more likely to identify as non-Hispanic black compared with patients with respiratory disease (35% versus 18%, P=.02). Seven patients (2%) died and 114 (41%) were admitted to the ICU. In multivariable analyses, obesity (OR=3.39, 95% CI:1.26-9.10, P=.02) and hypoxia on admission (OR=4.01; 95% CI:1.14-14.15; P=.03) were predictive of severe respiratory disease. Lower absolute lymphocyte count (OR=8.33 per unit decrease in 10(9) cells/L, 95% CI:2.32-33.33, P=.001) and higher C-reactive protein (OR=1.06 per unit increase in mg/dL, 95% CI:1.01-1.12, P=.017) were predictive of severe MIS-C. Race/ethnicity or socioeconomic status were not predictive of disease severity. CONCLUSIONS: We identified variables at the time of hospitalization that may help predict the development of severe SARS-CoV-2 disease manifestations in children and youth. These variables may have implications for future prognostic tools that inform hospital admission and clinical management.

is ?:annotates of