PropertyValue
?:abstract
  • Summary Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic Major efforts are underway to understand bat immune response to viruses, whereas much less is known about their immune responses to bacteria In this study, MR1-restricted T (MR1T) cells were detected through the use of MR1 tetramers in circulation and tissues of Pteropus alecto (Pa) bats Pa MR1T cells exhibited weak responses to MR1-presented microbial metabolites at resting state However, following priming with MR1-presented agonist they proliferated, upregulated critical transcription factors and cytolytic proteins, and gained transient expression of Th1/17-related cytokines and antibacterial cytotoxicity Collectively, these findings show that the Pa bat immune system encompasses an abundant and functionally conserved population of MR1T cells with MAIT-like characteristics, suggesting that MR1 and MR1T cells also play a significant role in bat immune defense
is ?:annotates of
?:creator
?:journal
  • iScience
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • MR1-restricted T cells with MAIT-like characteristics are functionally conserved in the pteropid bat Pteropus alecto
?:type
?:who_covidence_id
  • #947256
?:year
  • 2020

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/9azzua8w>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/9azzua8w>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all