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BACKGROUND The COVID-19 pandemic has highlighted the stark reality of city lockdowns, mass quarantines and social isolation worldwide. The importance of social isolation and quarantine measures to reduce community transmission of COVID-19 must be balanced against the potential impact on the psychological health of the population. OBJECTIVE The purpose of this article is to provide an overview of the psychological and social impacts of human isolation, how these may present and approaches to identifying and mitigating these effects. DISCUSSION Quarantine has been associated with increased rates of suicide, anger, acute stress disorder, depression and post-traumatic stress disorder, with symptoms continuing even years after quarantine ends. There are several predisposing risk factors including the inhabited environment, unique aspects of assessment as well as phenomena seen specifically among groups facing isolation together. The article provides management strategies for the general practitioner as well as indicators for referral to further psychological supports.
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