PropertyValue
?:abstract
  • BACKGROUND: Patients with chronic diseases usually develop severe 2019 coronavirus disease (COVID-19). However, little is known about the effects of COVID-19 on patients with neurological disorders. We conducted a systematic review to evaluate the severity of COVID-19 and its effect on preexisting neurological symptoms in patients with comorbid neurological disorder and COVID-19. METHODS: We searched the MEDLINE (PubMed) and medRxiv databases for reports of patients with both neurological disorders and COVID-19. Studies reporting data on changes in the symptoms of preexisting neurological disorders and/or the severity of COVID-19 were included. RESULTS: Twenty-six articles with 2278 patients with comorbid neurological disorder and COVID-19 were identified. Of 232 patients, 74 (31.9 %) showed exacerbation of preexisting neurological symptoms of dementia (55/92; 59.5 %), Parkinson’s disease (10/17; 58.8 %), epilepsy (1/1; 100 %), and unspecified neurological disorders (8/106; 7.5 %). Of 2168 patients, 478 (22.0 %) showed severe COVID-19 course. These included patients with cerebrovascular disease (86/445; 19.3 %), dementia (70/316; 22.2 %), Parkinson’s disease (25/214; 11.7 %), multiple sclerosis (28/71; 39.4 %), spinal cord injury (5/7; 71.4 %), and unspecified neurological disorders (254/1011; 25 %). CONCLUSIONS: Patients with comorbid neurological disorders and COVID-19 may develop more severe preexisting neurological symptoms and COVID-19. Clinicians should be aware of the risk of symptom exacerbation and severe COVID-19 in patients with neurological disease and should focus on the prevention and early care of COVID-19.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1016/j.clineuro.2020.106349
?:journal
  • Clin_Neurol_Neurosurg
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/6dbadb6e2f72bd6cf955e3bf1a5d34e4aef0f95c.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7604080.xml.json
?:pmcid
?:pmid
?:pmid
  • 33172719.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Exacerbation of preexisting neurological symptoms and COVID-19 severity in patients with comorbid neurological disorders and COVID-19: A systematic review
?:type
?:year
  • 2020-11-01

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