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Systems biology involves network-oriented, computational approaches to modeling biological systems through analysis of big biological data. To contribute maximally to scientific progress, big biological data should be FAIR: findable, accessible, interoperable and reusable Here, we describe high-throughput sequencing data that characterize the vast diversity of B- and T-cell clones comprising the adaptive immune system (AIRR-seq data) and its contribution to our understanding of COVID-19. We describe the accomplishments of the “adaptive immune receptor repertoire” (AIRR) Community, a grass-roots network of interdisciplinary laboratory scientists, bioinformaticists, and policy wonks, in creating and publishing standards, software and repositories for AIRR-seq data based on the FAIR principles.
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10.1016/j.coisb.2020.10.001
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document_parses/pdf_json/4656a6bfe4d750ff403d3f76e64bf0e990375ada.json
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document_parses/pmc_json/PMC7547575.xml.json
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Ms for Current Opinion in Systems Biology Special Issue on Systems Immunology The AIRR Community as a model for FAIR stewardship of big immunology data
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