PropertyValue
?:abstract
  • We are in the midst of a global viral pandemic, one with no cure and a high mortality rate The Human Leukocyte Antigen (HLA) gene complex plays a critical role in host immunity We predicted HLA class I and II alleles from the transcriptome sequencing data prepared from the bronchoalveolar lavage fluid samples of five patients at the early stage of the COVID-19 outbreak We identified the HLA-I allele A*24:02 in four out of five patients, which is higher than the expected frequency (17 2%) in the South Han Chinese population The difference is statistically significant with a p-value less than 10(-4) Our analysis results may help provide future insights on disease susceptibility
  • We are in the midst of a global viral pandemic, one with no cure and a high mortality rate The Human Leukocyte Antigen (HLA) gene complex plays a critical role in host immunity We predicted HLA class and Ialleles from the transcriptome sequencing data prepared from the bronchoalveolar lavage fluid samples of five patients at the early stage of the COVID-19 outbreak We identified the HLA-allele A*24:02 in four out of five patients, which is higher than the expected frequency (17 2%) in the South Han Chinese population The difference is statistically significant with a p-value less than 10-4 Our analysis results may helprovide future insights on disease susceptibility
?:creator
?:journal
  • ArXiv
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • HLA predictions from the bronchoalveolar lavage fluid samples of five patients at the early stage of the wuhan seafood market COVID-19 outbreak
?:type
?:who_covidence_id
  • #487
  • #832815
?:year
  • 2020

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