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  • A synthetic chlorophenyl-butanoic acid derivative with muscle relaxant activity. Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors in the central nervous system (CNS). At spinal and supraspinal sites, this agent reduces excitatory transmission. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28858\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28858\' NCI Thesaurus)
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