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  • Hypertrophy and hyperplasia of the juxtaglomerular apparatus with secondary hyperaldosteronism with normal blood pressure and hyperkalemic alkalosis in the absence of edema. Most patients show growth and mental retardation. Nephrocalcinosis and hypercalcinuria occur in some cases. Diuretic abuse may produce a syndrome with similar characteristics (pseudo-Bartter or factitious Bartter syndrome).
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