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  • Cellular senescence during AGING or due to extended passages of normal cells in culture and that is triggered by the DNA damage-response to TELOMERE SHORTENING or by repeated exposure to stress signals.
  • Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
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