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  • carbamate derivative used as an alcohol deterrent; it is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol; when alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome); it acts by inhibiting aldehyde dehydrogenase.
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