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  • The most frequently occurring mental retardation/multiple anomaly syndrome usually involving more than 100 individual defects. Typical facies with upslanting palpebral fissures is the characteristic feature of this syndrome (hence the offensive designations \'mongoloid idiocy\' and \'mongolism\'). A wide range other defects, such as congenital heart diseases, respiratory disorders, and leukemia, may be associated. Down syndrome patients who survive into late adulthood may develop Alzheimer syndrome.
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