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  • The most common chronic myeloproliferative disorder characterized by neutrophilic leukocytosis. It is associated with the Philadelphia (Ph) chromosome and/or the BCR/ABL fusion gene. Most patients are middle-aged or elderly. Common findings at presentation include fatigue, weight loss, anemia, night sweats, and splenomegaly. The disease is bi- or triphasic; an initial indolent chronic phase is followed by an accelerated or blast phase. Allogeneic bone marrow transplantation is currently the only curative therapy (adapted from WHO 2001). Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3174\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C3174\' NCI Thesaurus)
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