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measure of histocompatibility at the HLA locus: peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days; lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not; in the one-way MLC test, the lymphocytes from one of the individuals are inactivated thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
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