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  • A fluorinated isopropyl ether with anesthetic and muscle relaxant activities. Although the mechanism of action has not been fully elucidated, upon inhalation, methoxyflurane acts through multiple mechanisms of action. This agent interferes with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alters ionic conductance following receptor activation by a neurotransmitter, thereby disrupting neuronal transmission. In addition, this agent activates the inhibitory receptor gamma-aminobutyric acid (GABA). Altogether, this results in a general anesthetic effect and induces analgesia. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C75098\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C75098\' NCI Thesaurus)
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