?:definition
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A tubulointerstitial inflammatory disease involving a spectrum of lesions affecting the tubules, interstitium and/or the pelvis of the kidney. Pyelonephritis can result from infections, both ascending and descending and following papillary necrosis and urothelial ulceration. Certain strains of rodents are particularly susceptible to developing spontaneous pyelonephritis and are used as animal models to assess antibiotic therapy. (INHAND)
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