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  • An oligonucleotide synthesized from adenosine triphosphate (ATP) by enzymes in the 2\'-5\'-oligoadenylate synthase family. The production of 2\'-5\'-oligoadenylate is stimulated by the presence of double stranded RNA (dsRNA) and binds to inactive monomeric forms of ribonuclease L (RNase L), thereby promoting RNase L dimerization and activation. Active RNase L degrades both cellular and viral RNAs, which inhibits protein translation and leads to the abrogation of viral replication. 2\'-5\'-oligoadenylates play a key role in the innate immunity against viruses.
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