PropertyValue
?:definition
  • A ribonucleotide analog of adenosine monophosphate that is an intermediate in the synthesis of inosine monophosphate with potential cardioprotective activity. During myocardial ischemia, AICA-ribotide activates AMP-dependent protein kinase (AMPK), inhibits adenosine deaminase (ADA) and causes increased synthesis of both adenosine and adenosine triphosphate (ATP). These activities prevent calcium overload, increase AMPK-dependent glucose uptake and improve blood flow to the heart. AMPK, a protein kinase complex, regulates several cellular systems including the uptake of glucose, the beta-oxidation of fatty acids, protein synthesis, and the biogenesis of both glucose transporter 4 (GLUT4) and mitochondria. ADA is a key enzyme involved in purine metabolism.
?:hasCUIAnnotation
?:hasGeneratedBy
?:type

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/C0051028_NCI>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/C0051028_NCI>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all