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  • An agent derived from acetohydroxamic acid with potential antineoplastic activity. Caracemide inhibits ribonuclease reductase, resulting in decreased DNA synthesis and tumor growth; it also inhibits acetylcholinesterase. In vivo, caracemide contributes to the formation of the neurotoxin methyl isocyanate; this effect, along with the agent\'s acetylcholinesterase activity, may be responsible for the severe central nervous system toxicity observed in clinical trials. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1037\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1037\' NCI Thesaurus)
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