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  • intracellular knots or clumps of neurofibrils seen in various parts of the brain in Alzheimer\'s disease; composed of dense arrays of paired helical filaments (neurofilaments and microtubules) and incorporating the following proteins: intermediate filaments, medium and high molecular weight neurofilaments, microtubule associated proteins, map2 and tau, actin, and ubiquitins.
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