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  • Topoisomerase III belongs to type IA topoisomerases subfamily (includes archaebacterial reverse gyrase, bacterial topo I and topo III, which all form covalent 5\'phosphotyrosine linkage with cleaved DNA). Topo III does not play a major role in regulating DNA supercoiling, however, genetic experiments implicate that it plays a role in suppressing mitotic recombination and in resolving recombined homologous chromosomes during meiosis I. Topo III also has been demonstrated to interact with RecQ family of DNA helicases, which includes the Bloom\'s syndrome, Werner\'s syndrome, and Rothmund-Thomson syndrome gene products.
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