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  • WHAT: Anti-cytoplasmatic antibodies Antibodies to component of the cytoplasma of granulocytes. HOW: Anti-cytoplasmatic antibodies are detected by immunofluorescence with patient serum on granulocytes of donors. WHY: They are present in up to 70% of patients with Wegener\'s disease and are apparently quite specific for this disease. Several investigators were unable to demonstrate them in patients with other systemic diseases or autoimmune diseases. REFS: Cohen Tervaert et al. Association between active Wegener\'s granulomatosis and anti-cytoplasmatic antibodies. Arch Int Med 1989; 149:2461.
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