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  • A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod\'s proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1431\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1431\' NCI Thesaurus)
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