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Microtomes that cut tissue specimens for microscopic analysis in the histopathology laboratory using a steel, tungsten-carbide-tipped, or glass knife and that employs a drive wheel either to step the specimen into a stationary knife and ove it across the blade or to advance the knife toward a fixed specimen block. They are specially designed to cut thin sections of tissue that have been embedded in a medium (e.g., paraffin, plastic) and are convenient for high-volume routine sectioning. Tissue-block sections can be cut at 2 to 6 um. The major components are the feed pawl system, which steps the specimen into the knife or the knife into the specimen; the specimen cylinder; the flywheel; and the knife holder system. The knife holder system is adjustable and designed to accommodate various types of knives and to lock the knife into position for cutting
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