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  • Laboratory blood coagulation analyzers used to evaluate the adhesion of platelets to one another. These analyzers activate the aggregation process by adding an aggregating agent, such as adenosine diphosphate (ADP) or ristocetin. Platelet aggregation analyzers use optical density (turbidmetric), electrical impedance, or bioluminescence measuring methods. Usually, these analyzers require previous sample preparation, including centrifugation, to obtain platelet-rich plasma (PRP) and platelet-poor plasma (PPP) samples; but, some analyzers that use the impedance method of analysis can use whole blood. Platelet aggregation analyzers are used to distinguish between different types of platelet dysfunction (e.g., deficiency in platelet release substances, poor platelet adhesion to injured tissue).
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