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A localized clonal (malignant) plasma cell infiltrate in the bone without peripheral blood involvement. The most commonly affected bones are the vertebrae, ribs, skull, pelvis and femur. X-rays examination reveals a solitary lytic lesion. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7812\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C7812\' NCI Thesaurus)
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