PropertyValue
?:definition
  • A disulfide-linked homodimeric protein complex comprised of 2 platelet-derived growth factor subunit B proteins. This dimeric growth factor binds to a homodimeric receptor comprised of two platelet-derived growth factor receptor beta proteins. Ligand binding activates the intrinsic tyrosine-protein kinase activity of the receptor complex and initiates signal transduction pathways.
  • The recombinant analog of endogenous beta (B) chain of the cytokine platelet-derived growth factor (PDGF). Synthesized primarily by megakaryocytes, endogenous PDGF consists of two related peptide chains, PDGF-A and PDGF-B. PDGF functions as a local autocrine and paracrine growth factor in many cellular processes. Recombinant PDGF, alone and in combination with other agents, may be useful in promoting bone formation and soft tissue repair. (NCI04)
?:hasCUIAnnotation
?:hasGeneratedBy
?:type

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/C0379135_NCI>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/C0379135_NCI>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all