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  • Cancer that has spread to distant anatomic sites beyond its original site of growth. The definition of stage IVC depends on the particular type of cancer that it refers to; for example, for head and neck carcinomas (lip and oral cavity carcinoma, laryngeal carcinoma, nasal cavity and paranasal sinus carcinoma, pharynx carcinoma, thyroid gland carcinoma, and major salivary gland carcinoma) and head and neck mucosal melanoma, stage IVC is defined as follows: any T, any N, M1; for appendix carcinoma, stage IVC is defined as follows: any T, any N, M1b, any G. M1: Distant metastasis. M1b: Nonperitoneal metastasis. G: Grade (cellular differentiation).
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