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  • Grafts produced artificially (i.e., synthetically), which are intended to replace an area of a patient\'s diseased or injured skin. These grafts are typically a two-layer structure: an external layer strong enough to be sutured on the wound bed (also known as artificial epidermis), which consists of a silicone film intended to control wound moisture flux and bacterial infection; and an internal layer (i.e., the skin regeneration template, also known as artificial dermis) that includes type I collagen. The silicone layer is removed after 14 days and frequently replaced with a thin autograft or with an epidermis cultured in the laboratory from the patient\'s own epithelial cells when the internal layer has induced the synthesis of a new dermis.
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