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  • The hydrochloride salt form of fexofenadine, a carboxylated metabolic derivative of terfenadine and third generation selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Fexofenadine competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently histamine binding and activity as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandin and leukotriene precursors, is blocked, thereby preventing the triggering of pro-inflammatory pathways. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29050\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29050\' NCI Thesaurus)
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