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  • A vaccine consisting of recombinant vaccinia virus, based on the modified vaccinia virus Ankara (MVA), that encodes the melanoma-associated antigen tyrosinase. Vaccination with vaccinia-tyrosinase may stimulate the host immune system to mount a cytotoxic T-cell response against tumor cells expressing tyrosinase. Tyrosinase is a melanoma-specific differentiation agent that catalyzes the synthesis of the melanin precursor L-3,4-dihydroxyphenylalanine (L-DOPA). Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2531\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2531\' NCI Thesaurus)
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