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Hematology analyzers that require minimal involvement of technicians, with complete automation of sampling and dilution, cell counting, and red blood cell index determination; some include closed-tube sampling to automatically extract the blood sample from the phlebotomy tube. Most of these analyzers are based on fluorescence quantification and cytometry techniques or on electrical impedance (Coulter) techniques. Some automated hematology analyzers perform a three-part white blood cell differential count, while most provide a five-part count, differentiating all five types of normal white blood cells. Automated cell-counting hematology analyzers may include reticulocyte analysis capabilities.
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