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  • The major and active metabolic product of dietary indole-3-carbinol, present in a wide variety of plant food substances from the Cruciferae family, with cytostatic and antiestrogenic properties. 2-(indol-3-ylmethyl)-3,3\'-diindolylmethane is an antagonist of estrogen receptor, and could inhibit the proliferation of both estrogen-dependent and -independent breast cancer cells. In addition, this agent also activates binding of the aryl hydrocarbon (Ah) receptor to its cognate DNA responsive element and expression of the Ah receptor-responsive gene CYP1A1.
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