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  • A recombinant, humanized monoclonal antibody directed against CD22, a cell surface glycoprotein present on mature B-cells and on many types of malignant B-cells. After binding to CD22, epratuzumab\'s predominant antitumor activity appears to be mediated through antibody-dependent cellular cytotoxicity (ADCC). Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1887\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1887\' NCI Thesaurus)
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