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  • A synthetic peptide corresponding to the first 11 N-terminal amino acids of human lactoferrin (hLF1-11) with potential antimicrobial activity. Although the exact mechanism through which this peptide exerts its effect has yet to be fully elucidated, hLF1-11 binds ferric iron, limiting the availability of free iron for microbial functions. hLF1-11 may be effective against a variety of bacteria and fungi, including multidrug-resistant (MDR) strains of Acinetobacter baumannii and Staphylococcus aureus, and fluconazole-resistant Candida albicans strains. Human lactoferrin, a 692 amino acid glycoprotein belonging to the transferrin family of metal-binding proteins, can be found in human milk and other secretory fluids, and the secondary granules of polymorphonuclear (PMN) cells. Human lactoferrin plays a role in the innate defense of mucosal surfaces. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C67046\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C67046\' NCI Thesaurus)
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