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  • Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster. [GOC:jl, GOC:mr, ISBN:0140512888, PMID:11498577, PMID:20622855, Wikipedia:XY_sex-determination_system]
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