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  • The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania. [PMID:12152483, PMID:21514274, PMID:2659372, PMID:29091711, PMID:29409544]
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