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Regulatory T cells that express CD4 and CD25 (interleukin 2 receptor) antigens, with immunomodulating activity.. CD4+CD25+ T regulatory cells (Tregs), a subset of CD4+ T cells expressing high levels of CD25 and the transcription factor Foxp3, are essential in maintaining immunologic homeostasis, preventing autoimmunity by suppressing self-reactive T cells; CD4+CD25+ Tregs may induce tolerance to allogeneic organ transplants such as hematopoetic stem cell transplants (HSCTs). Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C78829\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C78829\' NCI Thesaurus)
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