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  • A cytochemical staining technique used to detect esterase enzyme contained within monocytes and macrophages, which reacts strongly with the substrate alpha-naphthyl butyrate. Monoblastic [FAB M5a (without differentiation) or M5b (with differentiation)] and acute myelomonocytic (M4) leukemias blasts stain when the butyrate substrate is used. Myeloid cells (either malignant or non-malignant) do not stain with nonspecific esterase techniques.
  • A cytochemical staining technique using the alpha-naphthyl esterase staining method or a nonspecific esterase staining method to identify and quantify monoblasts and monocytes and to detect esterase activity. The esterase enzyme contained within monocytes and macrophages reacts strongly with the substrate alpha-naphthyl butyrate. The test is useful in diagnosis of acute leukemias. It marks immature monocytes, and thus is useful in the diagnosis of acute myelogenous leukemia of monocytic type.
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