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  • A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use. Similar to most amino acids, fluorine F 18-fluciclovine ([18]FACBC) appears to enter cells through the energy-independent L-type amino acid transporter (LAT) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occuring amino acids, this non-natural amino acid-analogue radiotracer is not metabolized. Accordingly, [18]FACBC accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (PET). Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74002\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C74002\' NCI Thesaurus)
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