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Partitioning defective 6 homolog alpha (346 aa, ~37 kDa) is encoded by the human PARD6A gene. This protein is involved in tight junction formation, asymetrical cell division, and cell polarization processes as an adaptor signaling protein.
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This gene is involved in the cytoskeletal polarization of epithelial cells and also plays a role in neuronal cell migration and cytoskeletal rearrangements.
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